|  I was born in Hong Kong, a small subtropical city of a thousand square kilometers with seven million people. So my hometown, with a population density ranked the third highest in the world, is a super duper crowded city, but the hustle and bustle of everyday shopping in this shopping paradise is more exciting than you would imagine.
I received my bachelor's degree in biology from Hong Kong University of Science and Technology in 1999 and a master's degree in computing science from Imperial College London in 2000. After graduated, I had developed a career in the IT industry for five years until I decided to further study in computional biology. I then recieved my doctoral degree in bioinformatics at Yale Unverisity in 2010, followed by a postdoctoral trainning in computational genomics at Stanford University.
Research Interest
I have a broad research interest. My major area of research is computational analysis of genomic variation, particularly in humans, including structural variation (SV), copy number variation (CNV), segmental duplication (SD), and single nucleotide polymorphism (SNP). My research involves using high throughput sequencing technologies and developing computational algorithms, pipelines and methodologies to systematically and efficiently identify such variation. It aims to enhance the understanding of the mechanism and impact of genomic variation by facilitating analyses at a nucleotide level. A recent study of such has been reported on the Yale News and published in Nature Biotechnology. My other research interests include protein-protein interaction, such as predicting and analyzing the binding and interaction sites of proteins (e.g. transcription factors, SH3, and kinase), and also standardizing, annotating and integrating genomic and neuronal data.
Publication
Lam HY et. al. HugeSeq: an integrated pipeline for detecting and annotating genetic variations using high-throughput genome sequencing. Nature Biotechnology. In press. Lam HY et. al. Performance comparison of whole-genome sequencing platforms. Nature Biotechnology. 2011 Dec 18. doi: 10.1038/nbt.2065. [PubMed] Clark M, Chen R, Lam HY et. al. Exome DNA Sequencing: A Comparison of Enrichment Technologies. Nature Biotechnology. 2011 Sep 25;29(10):908-14. [PubMed] Stewart C, Kural D, Strömberg M, Walker JA, Konkel MK, Stütz AM, Urban AE, Grubert F, Lam HY et. al. A Comprehensive Map of Mobile Element Insertion Polymorphisms in Humans. PloS Genetics. 2011 Aug 20;7(8): e1002236. [PubMed] Zhang ZD, Du J, Lam HY et. al. Identification of genomic indels and structural variations using split reads. BMC Genomics. 2011 Jul 25;12(1):375. [PubMed] Mu XJ, Lu ZJ, Kong Y, Lam HY, Gerstein MB. Analysis of genomic variation in non-coding elements using population-scale sequencing data from the 1000 Genomes Project. Nucleic Acids Res. 2011 May 19. [PubMed] ENCODE Project Consortium. A user's guide to the encyclopedia of DNA elements (ENCODE). PLoS Biol. 2011 Apr;9(4):e1001046. [PubMed] Mills R et. al. & 1000 Genomes Project. Mapping copy number variation by population scale genome sequencing. Nature. 2011 Feb 3;470(7332):59-65. [PubMed] Shou C, Bhardwaj N, Lam HY et. al. Measuring the evolutionary rewiring of biological networks. PLoS Comput Biol. 2011 Jan 6;7(1):e1001050. [PubMed] 1000 Genomes Project Consortium. A map of human genome variation from population-scale sequencing. Nature. 2010 Oct 28;467(7319):1061-73. [PubMed] Khurana E, Lam HY et. al. Segmental duplications in the human genome reveal details of pseudogene formation. Nucleic Acids Res. 2010 Jul 8. [PubMed] Lam HY et. al. Motips: An Automated Motif Analysis Pipeline for Predicting Domain Targets. BMC Bioinformatics. 2010 May 11;11(1):243. [PubMed] Zhong M, Niu W, Lu Z, Sarov M, Murray J, Janette J, Raha D, Sheaffer K, Lam HY et. al. Genome-wide identification of binding sites defines distinct functions for C. elegans PHA-4/FOXA in development and environmental response. PloS Genetics. 2010 Feb 19;6(2):e1000848. [PubMed] Mok J, Kim PM, Lam HY et. al. Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation motifs. Science Signaling. 2010 Feb 16;3(109):ra12. [PubMed] Lam HY et. al. Nucleotide-resolution analysis of structural variants using BreakSeq and a breakpoint library. Nature Biotechnology. 2010 Jan;28(1):47-55. [PubMed] Lam HY et. al. Pseudofam: the pseudogene families database. Nucleic Acids Res. 2009 37(Database issue):D738-D743. [PubMed] Kim PM* & Lam HY* et. al. Analysis of copy number variants and segmental duplications in the human genome: Evidence for a change in the process of formation in recent evolutionary history. Genome Res. 2008 Dec;18(12):1865-74. [PubMed] Zhang ZD, Rozowsky J, Lam HY et. al. Tilescope: online analysis pipeline for high-density tiling microarray data. Genome Biol. 2007;8(5):R81. [PubMed] Lam HY et. al. AlzPharm: integration of neurodegeneration data using RDF. BMC Bioinformatics. 2007 May 9;8 Suppl 3:S4. [PubMed] Lam HY et. al. Using web ontology language to integrate heterogeneous databases in the neurosciences. AMIA Annu Symp Proc. 2006:464-8. [PubMed]
Education
2010- 2011. Postdoc. Computational Genomics (Genetics, School of Medicine) 2005- 2010. Ph.D. Computational Biology & Bioinformatics. 2005-2007. M.Sc. Computational Biology & Bioinformatics. 1999-2000. M.Sc. (Distinction) Computing Science. 1996-1999. B.Sc. (Class I) Biology. Work Experience
2004-2005. Software Engineer. University of Hong Kong. Hong Kong 2000-2004. Analyst Programmer. PCCW Limited. Hong Kong. Professional Qualification
2007. Sun Certified Enterprise Architect. Sun Microsystems. 2002. Sun Certified Web Component Developer. Sun Microsystems. 2001. Sun Certified Java Programmer. Sun Microsystems. Acknowledgement
The informatics training grant (2005-2008) from the National Library of Medicine. |
